Pencarian obat berdasarkan namanya

Plazomicin dan Disfungsi ginjal

Hasil pengujian interaksi obat Plazomicin dan penyakit Disfungsi ginjal untuk kontraindikasi dan efek samping dengan penggunaan bersama.

Hasil pengecekan:

Plazomicin <> Disfungsi ginjal

Aktualitas: 23.07.2019 Pemeriksa: Dr. P.M.Shkutko, in

Sesuai dengan informasi sumber yang dapat diandalkan Drugs.com, Rxlist.com, Webmd.com, Medscape.com, saat pemeriksaan interaksi efek samping dan kontraindikasi ditemukan, yang dapat membahayakan atau meningkatkan efek negatif saat penggunaan kombinasi obat-obatan dengan penyakit yang terkait.

Konsumen:

Aminoglikosida yang berpotensi oto - dan nefrotoksik. Kedelapan kranial kerusakan saraf dapat bermanifestasi sebagai vestibular dan/atau toksisitas auditori, termasuk pusing, nistagmus, vertigo, ataksia, tinnitus, dan berbagai derajat gangguan pendengaran. Nefrotoksisitas yang biasanya dibuktikan dengan nekrosis tubular; peningkatan BUN, nonprotein nitrogen dan kreatinin serum konsentrasi; mengurangi berat jenis urine dan kreatinin; proteinuria; dan sel-sel atau gips dalam urin. Jarang, ginjal membuang elektrolit dapat terjadi, yang mengakibatkan hipokalsemia, hipomagnesemia, dan hipokalemia yang mungkin terkait dengan paresthesia, tetani, kebingungan, dan Chvostek positif dan Trousseau tanda-tanda. Meskipun aminoglikosida - induced nefrotoksisitas ini umumnya reversibel setelah penghentian obat, kematian akibat uremia telah terjadi jarang. Terapi dengan aminoglikosida harus diberikan dengan hati-hati dengan pengurangan dosis pada pasien dengan gangguan ginjal, karena mereka mungkin pada peningkatan risiko untuk oto - dan nefrotoksisitas akibat akumulasi obat. Untuk meminimalkan risiko toksisitas, pasien harus cukup terhidrasi, biasa aminoglikosida dosis tidak boleh melebihi, gunakan dengan neuro - dan agen nefrotoksik harus dihindari, dan puncak dan palung serum aminoglikosida konsentrasi harus ditentukan secara berkala dan dosis disesuaikan untuk mempertahankan tingkat yang diinginkan. Ginjal dan saraf kranial kedelapan fungsi harus dimonitor dan dosis dikurangi atau terapi ditarik jika toksisitas berkembang.

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